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Do Bone Marrow Cells Generate Neurons?
David C. Hess, MD;
William D. Hill, PhD;
James E. Carroll, MD;
Cesar V. Borlongan, PhD
Arch Neurol. 2004;61:483-485.
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INTRODUCTION
In the past 5 years, accumulating evidence has demonstrated plasticity of bone marrow–derived cells. Bone marrow–derived cells display the capacity to change their fate, differentiating into hepatocytes, endothelial cells, muscle cells, and cardiomyocytes, and even neurons.1 The findings that bone marrow cells differentiate into neurons in vitro and in vivo challenge previous assumptions that tissue-specific stem cells give rise only to cells of their organ of origin and do not cross lineages.
Bone marrow contains a heterogeneous population of stem and progenitor cells. Two of the best defined are the hematopoietic stem cells and the bone marrow stromal cells or mesenchymal stem cells.1 There have been a number of reports of in vitro differentiation of bone marrow stromal cells into neurons on exposure to various inducing regimens.2
Co-isolating with mesenchymal stem cells is the . . . [Full Text of this Article]
DIFFERENTIATION OF BONE MARROW CELLS INTO NEURONS: EVIDENCE FROM ANIMAL STUDIES
EVIDENCE OF BONE MARROW–DERIVED NEURONS IN HUMANS?
FUSION
CONCLUSIONS
From the Departments of Neurology (Drs Hess, Hill, Carroll, and Borlongan) and Cell Biology and Anatomy (Dr Hill), and Institute of Molecular Medicine and Genetics (Drs Hess and Borlongan), Medical College of Georgia, and Veterans Affairs Medical Research Service (Drs Hess, Hill, and Borlongan), Augusta.
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