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The Pulvinar Sign in Variant Creutzfeldt-Jakob Disease
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We read with interest the article by Martindale et al1 regarding the presence of pulvinar hyperintensity on magnetic resonance (MR) images of a patient who was subsequently confirmed to have sporadic Creutzfeldt-Jakob disease (sCJD). Similar cases have previously been reported.2
Pulvinar hyperintensity was described as a characteristic feature of variant CJD (vCJD) in 2000.3 The original clinical criteria for a diagnosis of vCJD incorporated these MR imaging findings with diagnostic changes defined as "bilateral pulvinar high signal on MRI [magnetic resonance imaging] brain scan."4(p580) It was subsequently recognized that this definition was ambiguous because it was unclear with which structure the degree of pulvinar hyperintensity was compared.
Recently, a more specific definition of the pulvinar sign was included in the World Health Organization's revised case definition of vCJD.5 The new definition of the pulvinar sign in vCJD is "bilateral symmetrical pulvinar high signal relative to the signal intensity of other . . . [Full Text of this Article]
David M. Summers, MD;
Donald A. Collie, MD;
Martin Zeidler, MD;
Robert G. Will, MD
Edinburgh, Scotland
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Sporadic Creutzfeldt Jakob disease in two adolescents
Murray et al.
J. Neurol. Neurosurg. Psychiatry 2008;79:14-18.
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