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Arch Neurol. 2004;61:318.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

One of the major discoveries in dementia has been the linkage of a family with disinhibition-dementia-parkinsonism amyotrophy complex to chromosome 17.¹ Soon after that, several other families were linked to chromosome 17, many described before, under various names, such as hereditary dysphasic dementia² and pallido-ponto-nigral degeneration.³ It was soon recognized that all these conditions have clinical and pathological resemblance to sporadic frontotemporal dementia (FTD), primary progressive aphasia, and corticobasal ganglionic degeneration (CBD). A conference about chromosome 17–linked dementias agreed on the apt term frontotemporal dementia with parkinsonism linked to chromosome 17.⁴ Although Wilhelmsen considered tau the candidate gene, tau mutations were described later.^5-6

Not all dementias linked to chromosome 17 have tau mutations; probably only about 50% do. Approximately 25% to 40% of FTD is familial, and approximately 10% to 30% of patients with a positive family history have a mutation in tau.⁷ None of the sporadic . . . [Full Text of this Article]

Andrew Kertesz, MD, FRCPC
Department of Clinical Neurological Sciences
St. Joseph's Hospital
268 Grosvenor St
London, Ontario
Canada N6A 4V2
(e-mail: andrew.kertesz@sjhc.london.on.ca)

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