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Is the Picture Getting Simpler or More Complex?

Arch Neurol. 2004;61:176-177.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Fatigue is one of the most common and disabling symptoms of multiple sclerosis (MS).¹ Not only does fatigue affect up to 87% of patients with MS but as many as 40% of patients with MS regard fatigue to be their most disabling symptom.² Although several therapies have shown some promise in the treatment of fatigue in patients with MS, the lack of a truly effective treatment for this symptom may be due to the underlying pathophysiology for MS fatigue still being debated.

Many factors can contribute to fatigue experienced by patients with MS. In addition to the underlying disease process, factors such as depression, deconditioning, hypothyroidism, anemia, and medications can all contribute to fatigue in patients with MS, making the study of this phenomenon quite complex. Although fatigue in patients with MS can be worsened owing to depression and poor sleep habits, there are several clinical clues to suggest that . . . [Full Text of this Article]

Michael K. Racke, MD
Department of Neurology and the Center for Immunology
University of Texas Southwestern Medical Center
5323 Harry Hines Blvd
Dallas, TX 75390
(e-mail: michael.racke@utsouthwestern.edu)

Kathleen Hawker, MD; Elliot M. Frohman, MD, PhD
Dallas

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