 |
|
Channels and Disease
Past, Present, and Future
Louis J. Ptácek, MD;
Ying-Hui Fu, PhD
Arch Neurol. 2004;61:1665-1668.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
INTRODUCTION
Episodic neurological phenotypes make up an interesting and important group of diseases affecting humans. These include disorders of the skeletal and cardiac muscles, peripheral nerves, and brain. They range from episodic weakness syndromes to rare paroxysmal movement disorders. More common episodic phenomena include cardiac arrhythmias, epilepsy syndromes, and headache. Molecular characterization of these disorders is shedding light on their pathophysiologic features and will ultimately lead to better diagnosis and treatment of patients.
CLINICAL SIMILARITIES AMONG VARIOUS EPISODIC DISORDERS
Disorders such as the periodic paralyses, nondystrophic myotonias, episodic ataxias, paroxysmal dyskinesias, long QT syndrome, migraine headache, and epilepsy all share the feature of being episodic in nature. Affected individuals are often completely healthy between attacks. Stress and fatigue precipitate attacks in all of these diseases, and various dietary factors can also contribute to attack onset. The drugs used to treat these disorders overlap significantly. For example, carbonic anhydrase inhibitors are . . . [Full Text of this Article]
MOLECULAR CHARACTERIZATION OF EPISODIC NEUROLOGICAL PHENOMENA
NEW DIRECTIONS
Secondary Channelopathies Channels in Development Can New Phenotypes Be Recognizedin Some of These Disorders? Structural Proteins Contribute to Channel Localization and Function A Novel Epilepsy Gene Therapeutic Trials BenefitFrom Molecular Characterization COMMENT
AUTHOR INFORMATION
Author Affiliations: Howard Hughes Medical Institute (Dr Ptácek) and Department of Neurology (Drs Ptácek and Fu), University of California,San Francisco.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Reduced Sodium Current in Purkinje Neurons from NaV1.1 Mutant Mice: Implications for Ataxia in Severe Myoclonic Epilepsy in Infancy
Kalume et al.
J. Neurosci. 2007;27:11065-11074.
ABSTRACT
| FULL TEXT
New evidence for a genetic link between epilepsy and migraine
Winawer
Neurology 2007;68:1969-1970.
FULL TEXT
Recurrent Nocturnal Tongue Biting in a Child With Hereditary Chin Trembling
Goraya et al.
J Child Neurol 2006;21:985-987.
ABSTRACT
|
