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Emerging Antimicrobial-Resistant Infections
Karen L. Roos, MD
Arch Neurol. 2004;61:1512-1514.
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INTRODUCTION
Humanity has but three great enemies: fever, famine and war; of these by far the greatest, by far the most terrible, is fever. William Osler
The emergence of antimicrobial-resistant bacterial infections has changed the recommendations for the empirical therapy of community- and hospital-acquired meningitis. In the United States, approximately 34% of pneumococcal isolates are penicillin nonsusceptible, and approximately 14% are resistant to ceftriaxone.1 More than 50% of nosocomial infections in patients in the intensive care unit are due to methicillin-resistant Staphylococcus aureus.2-3 The first documented case of vancomycin-resistant S aureus was reported in the United States in 2002.4
The National Committee for Clinical Laboratory Standards establishes the standards for determining the susceptibility of bacteria to antibiotics based on the minimum inhibitory concentration (MIC). For pneumococcal meningitis, isolates with an MIC of 0.06 µ g/mL or less are considered susceptible to penicillin, those with an . . . [Full Text of this Article]
AUTHOR INFORMATION
Author Affiliation: Department of Neurology, Indiana University School of Medicine, Indianapolis.
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