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Windows Into Neuronal Function and Tumor Immunity

Robert B. Darnell, MD, PhD

Arch Neurol. 2004;61:30-32.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Neurologists have been fascinated by the paraneoplastic neurologic disorders (PNDs) for over a century. In the past 20 years, PNDs have emerged as prime examples of the way in which modern molecular biology can be used to transform esoteric medicine into widely applicable scientific and clinical insights.

Patients with PNDs typically exhibit rapid-onset, severe, and focal neurologic disease on initial examination. Magnetic resonance imaging findings are usually normal, and medical history and physical examinations yield no obvious cause for the disorders. An occult malignancy is usually discovered as patients are followed up or when a PND diagnosis is suspected.

It is believed that such malignancies underlie the neurologic degeneration in PNDs. More specifically, breast, ovarian, or small cell lung cancer (or sometimes other tumor types [Table 1]) are found to be present, often only in a lymph node or as a small focus . . . [Full Text of this Article]

PNDs AND NEURON-SPECIFIC GENE REGULATION

PND ANTIGENS AND HUMAN TUMOR IMMUNITY

From the Department of Molecular Neuro-Oncology, Howard Hughes Medical Institute, Rockefeller University, New York, NY.

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