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When Is Ataxia Not Ataxia?
Arch Neurol. 2004;61:25-26.
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Genetic evidence now firmly supports the "out of Africa" hypothesis for human migration, with people dispersing from Africa toward Europe and, largely separately, toward Asia. These 3 major populations are genetically distinct, with those of African descent having the greatest genetic diversity and those of Asian and European descent having less diversity, with origins from smaller groups.1 Nearly all diseases have been clinicopathologically defined in white populations, and yet this group has the least genetic diversity, limiting such definitions.1 We have functioned with the implicit assumption that diseases will be clinically similar in all populations. However, the article by Lu and colleagues2 in this issue of the ARCHIVES offers further evidence that this pervasive but unlikely supposition is not correct, by confirming previous studies that spinocerebellar ataxia type 2 (SCA2) is a cause of familial parkinsonism and can be identical to typical Parkinson disease (PD) symptomatically.1-7 Their work also reveals . . . [Full Text of this Article]
Katrina Gwinn-Hardy, MD
Laboratory of Neurogenetics, Parkinson's Unit
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Bethesda, MD 20892
(e-mail: gwinnk@ninds.nih.gov)
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The Parkinsonian Phenotype of Spinocerebellar Ataxia Type 2
Chin-Song Lu, Yah-Huei Wu Chou, Pei-Chi Kuo, Hsiu-Chen Chang, and Yi-Hsin Weng
Arch Neurol. 2004;61(1):35-38.
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