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Can an NSAID a Day Keep Parkinson Disease Away?

Arch Neurol. 2003;60:1043-1044.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

CLINICALLY APPLICABLE and effective maneuvers to protect the nervous system from selective neurodegenerative diseases have been elusive. Although the etiology and pathogenesis of Alzheimer disease (AD), amyotrophic lateral sclerosis, and idiopathic Parkinson disease (PD) are distinctly different, they share common pathogenic mechanisms in the process of neuronal cell death and degeneration. There is substantial evidence of a role for glial cell–mediated inflammation in the neurodegenerative process responsible for AD, amyotrophic lateral sclerosis, and PD.^1-3 This inflammatory response is an obvious target for potential therapeutic intervention. By far, the largest number of epidemiological studies and clinical trials analyzing the effects of modulators of inflammation (namely nonsteroidal anti-inflammatory drugs [NSAIDs],⁴ steroids, hormones, and aspirin) on disease risk,⁵ rate of progression, and cognitive function have been conducted on patients with AD. Despite the many studies, the outcomes have been inconsistent and inconclusive and have not permitted a consensus for any of these modulators . . . [Full Text of this Article]

Mya Schiess, MD
Department of Neurology, MSB 7.044
University of Texas–Houston Medical School
6341 Fannin St
Houston, TX 77030-1501
(e-mail: mya.c.schiess@uth.tmc.edu)

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