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  Vol. 60 No. 7, July 2003 TABLE OF CONTENTS
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The Diagnosis of Alzheimer Disease Before It Is Alzheimer Dementia—Reply

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In reply

I appreciate that Frisoni and colleagues took our previous results, placed them into a clinical context, and concluded that detection of the biological fingerprint of AD in patients with MCI might be sufficiently accurate for clinical decisions.

In our exploratory study, we identified elevated tau protein and decreased A{beta}42 protein concentrations at baseline in the CSF of patients with MCI who subsequently progressed to AD, yielding sensitivity and specificity values of 90% each. We also observed elevated CSF tau protein concentrations in subjects with MCI who showed a worsening of cognitive symptoms that was not severe enough to fulfill the diagnostic criteria of AD. Logistic regression analysis identified tau as the only variable among several others that predicted the progression of clinical symptoms. Therefore, elevated tau protein in CSF as a marker of neuronal degeneration and to a lesser extent decreased A{beta}42 protein may be the . . . [Full Text of this Article]


RELATED ARTICLE

The Diagnosis of Alzheimer Disease Before It Is Alzheimer Dementia
Giovanni B. Frisoni, Alessandro Padovani, and Lars-Olof Wahlund
Arch Neurol. 2003;60(7):1023.
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