This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (7)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Neuropathology  • Prion Diseases  • Pathology & Laboratory Medicine  • Alert me on articles by topic

Variability of Sporadic Creutzfeldt-Jakob Disease, Laboratory Standards, and Quantitation

Arch Neurol. 2003;60:803-804.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

THE CONCENTRATION in cerebrospinal fluid (CSF) of a constitutive neuronal protein known as 14-3-3 protein has been noted to be increased in patients with Creutzfeldt-Jakob disease (CJD).^1-2 A study in this month's ARCHIVES³ challenges the clinical utility of using elevated 14-3-3 protein levels as confirmation for diagnosis of sporadic CJD. This important study points out flaws in the clinical application of this laboratory analysis for CSF proteins that are not pathogenetically linked to the underlying disorder.

The 14-3-3 proteins are a family of intracytoplasmic cell-signaling proteins present in mammalian cells, flies, yeast, and plants.⁴ These proteins have been assigned diverse biochemical functions, including inhibition of protein-kinase C, effectors of serine phosphorylation, activators of protein kinase, regulators of apoptosis, exocytosis, and the cell cycle. Multiple cellular isoforms exist and are labeled alpha through tau. Biochemically, these proteins are acidic and have a molecular weight of 27 to 30 kDa. The beta, . . . [Full Text of this Article]

Allen J. Aksamit, MD
Department of Neurology
Mayo Clinic
200 First St SW
Rochester, MN 55905
(e-mail: aksamit.allen@mayo.edu)

RELATED ARTICLE

Challenging the Clinical Utility of the 14-3-3 Protein for the Diagnosis of Sporadic Creutzfeldt-Jakob Disease
Michael D. Geschwind, Jennifer Martindale, Deborah Miller, Stephen J. DeArmond, Jane Uyehara-Lock, David Gaskin, Joel H. Kramer, Nicholas M. Barbaro, and Bruce L. Miller
Arch Neurol. 2003;60(6):813-816.
ABSTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Time-course studies of 14-3-3 protein isoforms in cerebrospinal fluid and brain of primates after oral or intracerebral infection with bovine spongiform encephalopathy agent
Yutzy et al.
J. Gen. Virol. 2007;88:3469-3478.
ABSTRACT | FULL TEXT  

Discrepancies in the Clinical Utility of the 14-3-3 Protein for the Diagnosis of Sporadic Creutzfeldt-Jakob Disease
Sanchez-Valle et al.
Arch Neurol 2004;61:604-604.
FULL TEXT