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Neuropathologic Changes in Parkinson Disease With Late Onset of Dementia—Reply
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In reply
We thank Jellinger and colleagues for their interest in our article. They are correct in indicating that our series constituted a "highly selected cohort." We were interested in a defined group of patients: those with well-documented, typical PD and late-developing dementia (representative of certain patients we see in our clinic). Brain banks, including ours, notoriously contain heterogeneous cases. Even in the best of circumstances, adequate clinical documentation may sometimes be lacking. Furthermore, brain banks tend to favor atypical as well as complex cases.1 In our series, we set a premium on a well-documented and uniform clinical picture. We used the extensive clinical records from the Mayo Clinic (Rochester, Minn), available for all of our patients, to exclude anyone who did not fit our stringent criteria. If there was inadequate documentation, the case was excluded. We started with 162 cases from our PD brain bank, of which 64 had . . . [Full Text of this Article]
RELATED ARTICLE
Neuropathologic Changes in Parkinson Disease With Late Onset of Dementia
Kurt A. Jellinger, Klaus Seppi, and Gregor K. Wenning
Arch Neurol. 2003;60(3):452-453.
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