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In a prospective series of 333 patients with dementia, Lopez et al¹ described 11 patients who were diagnosed as having probable dementia with Lewy bodies (DLB) and 35 with possible DLB. Patients in both cohorts (5 vs 34, respectively) were found to have probable Alzheimer disease (AD); Parkinson disease (PD) was found in 2, whereas 3 patients had probable DLB alone. Autopsies performed on 26 patients in this series revealed cortical Lewy bodies in 13 cases, 4 with premortem diagnosis of DLB (sensitivity, 30.7%; specificity, 100%). Because few data exist on the prospective validation of consensus criteria for the diagnosis of DLB,² we briefly present the results of a personal retrospective clinicopathologic cohort study of patients with dementia, including 31 cases of DLB, 48 cases of AD, and 20 patients with PD and delayed-onset dementia.³

Clinical and neuropathologic diagnoses were established according to recent criteria for AD and DLB. First . . . [Full Text of this Article]