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Arch Neurol. 2003;60:161-163.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

APOLIPOPROTEIN E (APOE) is the most upstream member of a large cluster of apolipoprotein genes that are coregulated, at least in the liver and kidneys, by the interaction of the individual gene promoters with a set of shared enhancer elements.¹ APOE has been extensively investigated because of its role in lipid metabolism and ischemic cardiovascular disease,^2-5 but more recently because of its association with Alzheimer disease. In addition to Alzheimer disease and heart disease, the variants of APOE have also been associated with cerebral hemorrhage accompanying amyloid angiopathy and longevity.^6-7

Of the 3 common forms of APOE (2, 3, and 4) 3 is by far the most common variant, occurring in 60% to 80% of humans. APOE 4 is considered to be the ancestral allele. Among Europeans, the frequency of APOE 4 varies from about 30% among Lapps, Swedes, and Finns to 10% to 12% among Greeks . . . [Full Text of this Article]

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