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Stroke Risk, Hypertension, and HRTless Postmenopausal Therapy
Arch Neurol. 2003;60:1363-1364.
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RESULTS OF A STUDY by Løkkegaard et al1 in this month's ARCHIVES suggest that particular caution be given to the prescription of hormone therapy (HRT) to hypertensive postmenopausal women, at least in terms of increased risk for stroke. This study addressed stroke risk during a 5-year period in 13 122 healthy postmenopausal women who participated in the Danish Nurse Cohort Study.2 Participants were studied by means of an initial questionnaire, and outcomes, by means of periodic sampling of the National Patient Registry of Hospital Discharges, which registers all hospital admissions in Denmark. The salient finding of the Løkkegaard study is that although no risk for total stroke was found with HRT use, there was significant 5-year hazard with the use of combined HRT in hypertensive women for ischemic stroke (hazard ratio, 5.01; 95% CI, 2.09-12.00). The study also noted lesser hazard for uncombined estradiol use in ischemic stroke and for combined . . . [Full Text of this Article]
Douglas A. Dulli, MD, MS
Department of Neurology
University of Wisconsin Medical School
Clinical Science Center H6/574
600 Highland Ave
Madison, WI 53792
(e-mail: dulli@neurology.wisc.edu)
RELATED ARTICLE
Increased Risk of Stroke in Hypertensive Women Using Hormone Therapy: Analyses Based on the Danish Nurse Study
Ellen Løkkegaard, Zorana Jovanovic, Berit L. Heitmann, Niels Keiding, Bent Ottesen, Yrsa Andersen Hundrup, Erik B. Obel, and Annette Tønnes Pedersen
Arch Neurol. 2003;60(10):1379-1384.
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