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Arch Neurol. 2003;60:1363-1364.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

RESULTS OF A STUDY by Løkkegaard et al¹ in this month's ARCHIVES suggest that particular caution be given to the prescription of hormone therapy (HRT) to hypertensive postmenopausal women, at least in terms of increased risk for stroke. This study addressed stroke risk during a 5-year period in 13 122 healthy postmenopausal women who participated in the Danish Nurse Cohort Study.² Participants were studied by means of an initial questionnaire, and outcomes, by means of periodic sampling of the National Patient Registry of Hospital Discharges, which registers all hospital admissions in Denmark. The salient finding of the Løkkegaard study is that although no risk for total stroke was found with HRT use, there was significant 5-year hazard with the use of combined HRT in hypertensive women for ischemic stroke (hazard ratio, 5.01; 95% CI, 2.09-12.00). The study also noted lesser hazard for uncombined estradiol use in ischemic stroke and for combined . . . [Full Text of this Article]

Douglas A. Dulli, MD, MS
Department of Neurology
University of Wisconsin Medical School
Clinical Science Center H6/574
600 Highland Ave
Madison, WI 53792
(e-mail: dulli@neurology.wisc.edu)

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