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Brain Development in Healthy, Hyperactive, and Psychotic Children
Nitin Gogtay, MD;
Jay Giedd, MD;
Judith L. Rapoport, MD
Arch Neurol. 2002;59:1244-1248.
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INTRODUCTION
Serious and chronic childhood psychiatric disorders have long been assumed
to reflect relatively subtle abnormalities of brain development. Although
diagnostic brain imaging is well established in pediatric neurology, it has
not yet permitted quantitative assessment of brain abnormalities in children
with psychiatric illnesses. Recent advances in brain magnetic resonance imaging
(MRI) allow reliable, automated, quantitative measurement of multiple brain
regions.1 The noninvasive nature of MRI also
allows periodic rescanning for research purposes, making prospective longitudinal
study of brain development feasible in large numbers of healthy children and
those with psychiatric illness.2-3
Longitudinal MRI of the brain also makes possible the mapping of region-specific
changes in brain volume over time.4
Large, prospective MRI studies of the brains of hyperactive, psychotic,
and, perhaps most important, healthy children and adolescents aged 4 to 18
years have been undertaken at the National Institute of . . . [Full Text of this Article]
METHODS
RELEVANCE TO THE PRACTICE OF NEUROLOGY
RELEVANCE TO THE STUDY OF NEUROSCIENCE
From the Child Psychiatry Branch, National Institute of Mental Health,
Bethesda, Md.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Rosa-Neto et al.
Arch Gen Psychiatry 2004;61:556-563.
ABSTRACT
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