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Darts in the Dark Cure Animal, but Not Human, Brain Tumors
Arch Neurol. 2002;59:721-724.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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DURING THE past century, scientists have uncovered new knowledge in
molecular genetics and generated novel tools for manipulating the molecules
of the cell. Recent molecular strategies have shown promise in animal models.
However, there are shortcomings in our current experimental systems and methods,
resulting in failed experimental strategies. The goal of this article is to
discuss current modes of treatment, recent molecular strategies that have
shown promise in preclinical models, shortcomings in our current experimental
systems and methods, and why our experimental strategies have failed to translate
to beneficial treatments for patients suffering from brain tumors.
CURRENT MODES OF TREATMENT
Malignant brain tumors arise in more than 40 000 people in the
United States each year; they constitute the second most common cause of cancer-related
death in people 35 years and younger, with a slight peak of incidence in children
between the ages of 6 and 9 years. The standard treatment of anaplastic gliomas
and . . . [Full Text of this Article]
PROMISING MOLECULAR STRATEGIES
GENETIC HOMOGENEITY OF ANIMALS VS HETEROGENEITY OF HUMANS
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