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A Null Mutation in the CNTF Gene Is Not Associated With Early Onset of Multiple Sclerosis
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In a previous ARCHIVES article, Giess et al1 reported an association of a null mutation in the CNTF gene with early onset of multiple sclerosis (MS). Because CNTF has myeloprotective and survival-promoting effects on neuronal cells, homozygosity for the null mutation (–/- genotype) may affect disease outcome. The authors identified 7 (2.4%) of 288 patients with MS as carriers of this genotype. These patients had a significantly earlier onset of the disease (median, 17.0 years; 25th percentile, 16.3 years; 75th percentile, 24.0 years) compared with patients carrying at least 1 functional CNTF allele (median, 27.0 years; 25th percentile, 22.0 years; 75th percentile, 33.0 years; P = .007 using the Mann-Whitney test).
We recently reported finding homozygosity for the null mutation in 10 (2.9%) of 349 patients with MS as compared with 8 (1.8%) of 434 healthy controls.2 There was no significant correlation between the CNTF genotype and age at onset, . . . [Full Text of this Article]
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