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Arch Neurol. 2002;59:1717-1720.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

A NEW PACE of discovery has been achieved for regeneration research that inspires hope for future therapies aimed at repairing the injured central nervous system (CNS). Perhaps the most noticeable development has been a widening of the conceptual framework for how regeneration can be directed. Until recently, regeneration approaches centered on the classical view that injured nerves lack tropic support for regrowth. Today, neurobiologists are promoting neural regeneration using multiple approaches that include manipulation of the immune system, extracellular matrix, or growth-associated genes. Perhaps most exciting, recent data suggest that the adult CNS may be capable of impressive self-repair, encouraged through activity or physical rehabilitation. In this editorial we highlight some recent reports of CNS regeneration and consider them in the context of the unique set of challenges associated with the adult brain.

IDENTIFYING ENDOGENOUS BARRIERS TO REGENERATION

It is commonly believed that adult neurons contain the capacity to regrow if provided with an appropriate . . . [Full Text of this Article]

MYELIN-DERIVED FACTORS

REACTIVE FACTORS

GROWTH-PROMOTING SUBSTRATES IN THE ADULT CNS

THE CAPACITY TO GROW: HOW DO NEURONS INTERPRET THE CUES FOR GROWTH?

REGENERATING THE ADULT CNS: PUTTING PRINCIPLES INTO PRACTICE
Removal of Growth Inhibition

Manipulation of Intrinsic Regeneration Mechanisms

Self-repair: Activity and Rehabilitation

LOOKING AHEAD


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