This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (14)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Genetic Counseling/ Testing/ Therapy  • Neurogenetics  • Aging/ Geriatrics  • Alert me on articles by topic

Arch Neurol. 2002;59:1712-1714.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

OUR LABORATORIES have collaborated to begin defining gene expression profiles associated with the aging process in the postmitotic tissues of mice, such as the skeletal muscle,¹ brain,² and heart.³ To determine the influence of aging on gene expression in the muscle and brain, we employed Affymetrix (Santa Clara, Calif) oligonucleotide microarrays representing 6347 genes and compared young (5 months) and old (30 months), normally fed, male C57BL/6 mice. Additionally, the normally fed 30-month-old mice have been compared with age-matched mice subjected to caloric restriction (CR) since 2 months of age. The calorie-restricted mice are known to age at a slower rate and to live approximately 40% longer than do the controls.⁴ Regarding central nervous system aging, CR in laboratory rodents opposes the development of age-associated deficits in psychomotor and spatial memory tasks,⁵ dendritic spine loss,⁶ and neuronal degeneration in models of Parkinson disease.⁷

The decision to investigate postmitotic tissues was . . . [Full Text of this Article]

THE GENE EXPRESSION PROFILE OF THE AGED MOUSE BRAIN


TRANSCRIPTIONAL REPROGRAMMING IN THE BRAINS OF CALORIE-RESTRICTED MICE

PRESENT PURSUITS AND FUTURE GOALS

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Gene expression analysis in mice with elevated glial fibrillary acidic protein and Rosenthal fibers reveals a stress response followed by glial activation and neuronal dysfunction
Hagemann et al.
Hum Mol Genet 2005;14:2443-2458.
ABSTRACT | FULL TEXT  

The Future of Aging Interventions: Current Status of Efforts to Measure and Modulate the Biological Rate of Aging
Warner
J. Gerontol. A Biol. Sci. Med. Sci. 2004;59:B692-B696.
ABSTRACT | FULL TEXT