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Diagnosing Dementia With Lewy Bodies
Arch Neurol. 2002;59:29-30.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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LEWY BODY INCLUSIONS in neurons of the substantia nigra are universally
recognized as the histopathological signature of idiopathic Parkinson disease
(PD). Even though occasional cortical Lewy bodies can be detected in most
cases of idiopathic PD, it was not until 1984 that Kosaka et al1
linked the presence of cortical Lewy bodies to dementia. Recognition of dementia
with Lewy bodies (DLB) as a distinct neurodegenerative disease is therefore
relatively recent, and its definition is still evolving as physicians and
neuroscientists delineate its clinical and pathological dimensions. The current
consensus guidelines for the pathological diagnosis of DLB2
closely follow Kosaka's original formula for describing the distribution of
Lewy bodies: brainstem (idiopathic PD), limbic/transition, and neocortical
(DLB). From the earliest pathological studies, however, the majority of DLB
cases displayed some of the pathological changes associated with Alzheimer
disease (AD), especially senile plaques (Figure 1). In this issue of the ARCHIVES, . . . [Full Text of this Article]
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