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Mesial Temporal Sclerosis
Clinicopathological Correlations
Robert Edward Hogan, MD
Arch Neurol. 2001;58:1484-1486.
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INTRODUCTION
Mesial temporal sclerosis (MTS), which involves neuronal loss and gliosis
within the mesial temporal structures (primarily in Sommer sector and the
CA4 region of the hippocampus),1 is an important
cause of temporal lobe epilepsy.2 The syndrome
of mesial temporal lobe epilepsy includes febrile seizures, onset of complex
partial seizures in adolescence or early adulthood, poor response to antiepileptic
medications, and MTS.3 The modern understanding
of MTS and its relationship to epilepsy, which has mirrored our understanding
of epilepsy in general, has evolved since the description of hippocampal lesions
in a group of patients with epilepsy in 1825.4
CLINICOPATHOLOGICAL REPORTS
In 1825, Bouchet and Cazauvielh4 published
a pathological series of 18 patients with epilepsy, 8 of whom had palpable
firmness of the mesial temporal structures. In describing case 15 of their
series, they wrote
"The white matter of Ammon's horn is hard and comes off in fragments.
The left . . . [Full Text of this Article]
JOHN HUGHLINGS-JACKSON
OTHER BRITISH AND GERMAN CONTRIBUTIONS
PHYSIOLOGICAL AND SURGICAL ADVANCES
From the Department of Neurology, Saint Louis University, St Louis,
Mo.
Corresponding author and reprints: Robert Edward Hogan, MD, Department
of Neurology, Saint Louis University, 3635 Vista Ave, St Louis, MO 63110 (e-mail:
hoganr2@slu.edu).
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Hippocampal deformation mapping in MRI negative PET positive temporal lobe epilepsy
Hogan et al.
J. Neurol. Neurosurg. Psychiatry 2008;79:636-640.
ABSTRACT
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