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Optical Imaging and Its Role in Clinical Neurology
Susan V. Szapiel, MD
Arch Neurol. 2001;58:1061-1065.
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INTRODUCTION
Rapid advances and developments in optical imaging technology during
the past 15 years have resulted in promising innovations in the realm of high-resolution
imaging of the functional architecture of the brain, which has not only contributed
to the elucidation of brain functional architecture and plasticity (see reviews1, 2, 3, 4, 5, 6, 7)
but has also increased our understanding of the temporal and spatial dynamics
of cortical seizure spread,1, 2, 6, 8
led to related technical improvements in neurosurgical procedures for the
surgical resection of seizure foci,8 and may
help to provide more accurate resection of brain tumors9
as well as contribute to our understanding of higher cognitive function.
At present, various methodologies exist for the investigation of brain
structure and function, ranging from single-cell electrode recordings to imaging
the activity of large populations of neurons. However, they vary widely in
their degree of spatial and temporal resolution (Figure 1). Despite being . . . [Full Text of this Article]
HISTORY
METHODS
CLINICAL APPLICABILITY
NEUROSCIENCE APPLICATIONS
From the Department of Psychology and the Center for Molecular and
Behavioral Neuroscience, Rutgers–The State University of New Jersey,
Newark.
Corresponding author and reprints: Susan V. Szapiel, MD, Department
of Psychology, Rutgers–The State University of New Jersey, 101 Warren
St, Newark, NJ 07102 (e-mail: szapiel@psychology.rutgers.edu).
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