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Titin, Thymoma, and Myasthenia Gravis
Arch Neurol. 2001;58:869-870.
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TITIN WAS FIRST described in 1977 and given the name connectin.1 This giant, filamentous protein found in striated
muscle was not demonstrated earlier because its size made it inaccessible
to most techniques employed for protein identification. Titin is the largest
molecule so far identified in the human body and has a molecular weight of
about 3000 kd. Although abundant, it constitutes only approximately 10% of
the total protein mass of striated muscle. Each titin molecule spans a half
sarcomere, from the Z disk to the M line.2
The titin filaments contribute to muscle assembly and to the ability of muscle
to spring back after it is stretched. Length changes in titin during stretching
and contraction occur mainly in the I band, while the A band is functionally
stiff and highly ordered.
Antibodies to titin were first discovered in the serum of patients with
myasthenia gravis (MG) in 1990.3 Under immunoelectron
. . . [Full Text of this Article]
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Arch Neurol. 2001;58(6):885-890.
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