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Therapeutic Interventions Following Mammalian Spinal Cord Injury
Alexander G. Rabchevsky, PhD;
George M. Smith, PhD
Arch Neurol. 2001;58:721-726.
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INTRODUCTION
Every year in the United States spinal cord injuries (SCIs) occur in
approximately 12 000 individuals, resulting in chronic, debilitating
functional deficits in most of these patients. Owing to the extremely high
costs associated with hospitalization, subsequent rehabilitation, and outpatient
care, it is becoming evident that effective treatments for SCI could drastically
reduce health care costs and, more importantly, improve the quality of life
for thousands of individuals. In this review, we will briefly discuss the
pathological events that contribute to the poor regenerative capacity of the
injured spinal cord and describe experimental methods that are being used
to both minimize tissue damage and promote the regrowth of injured spinal
cord axons.
THE PATHOLOGY OF SCI
The pathophysiology of acute SCI involves a complex cascade of events
resulting in compromised function below the level of the injury. This is due
to significant neuronal death and the failure . . . [Full Text of this Article]
GLIOSIS AND ABORTIVE REGENERATION
WHAT ARE APPROPRIATE MODELS FOR EXPERIMENTAL SCI?
PHARMACOLOGICAL THERAPY FOLLOWING SCI
TRANSPLANTATION
Fetal Spinal Cord Tissue and Stem Cells Schwann Cells and Olfactory Ensheathing Cells Oligodendrocytes Astrocytes Microglial Cells Genetically Modified Fibroblasts
GENE THERAPY
CONCLUSIONS
From the Sanders-Brown Center on Aging (Dr Rabchevsky) and the Department
of Physiology, Albert B. Chandler Medical Center (Dr Smith), University of
Kentucky, Lexington.
Reprints: George M. Smith, PhD, Department of Physiology, MS 508,
University of Kentucky, Albert B. Chandler Medical Center, Lexington, KY 40536-0298
(e-mail: gmsmith@pop.uky.edu).
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