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Amyotrophic Lateral Sclerosis
The Search for a Spectroscopic Marker of Upper Motoneuron Involvement
Arch Neurol. 2001;58:714-716.
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CURRENTLY, the antemortem diagnosis of sporadic amyotrophic lateral
sclerosis (ALS) is based on a combination of clinical, electrophysiologic,
and sometimes muscle biopsy findings, and exclusion of other conditions that
might produce the clinical picture. There is no definitive diagnostic test
for the disease, and there is no established technique for demonstrating upper
motoneuron involvement except for the clinical neurologic examination. For
these reasons, there has been an interest in the past decade in the use of
in vivo magnetic resonance (MR) imaging and spectroscopy of the brain to diagnose
ALS and to monitor its progression. The initial focus was on MR imaging features,
such as hyperintensity in the corticospinal tracts on proton density–weighted
images and hypointensity in the motor cortex on T2-weighted images.1 These features, however, are present in less than
half of patients with clinically diagnosed ALS, and motor cortex hypointensity
can be observed in normal volunteers and in . . . [Full Text of this Article]
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Christoph Pohl, Wolfgang Block, Jochen Karitzky, Frank Träber, Stephan Schmidt, Christoph Grothe, Rolf Lamerichs, Hans Schild, and Thomas Klockgether
Arch Neurol. 2001;58(5):729-735.
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