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Huntington Disease
Eric Siemers, MD
Arch Neurol. 2001;58:308-310.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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INTRODUCTION
Huntington disease (HD) is a genetically transmitted, gradually progressive
disorder characterized by involuntary movements and dementia, with an average
duration of 17 years between onset of symptoms and death. Whereas current
research focuses primarily on molecular biology and novel treatments, these
efforts are based on initial observations by clinicians who were able to discern
the constellations of symptoms linked to the disorder.
EARLY DESCRIPTIONS
In obedience to your kind request, I improve my first leisure
since my return home in giving you, in as lucid and satisfactory a manner
as possible, an account of a singular affection somewhat common in the southeastern
portion of this State [New York], and known among the common people as "the
magrums." Whence the name originated I do not know. . . . The disease
is markedly hereditary, and is most common among the lower classes, though
cases of it are not infrequent among those . . . [Full Text of this Article]
GEORGE HUNTINGTON'S CONTRIBUTIONS
CRITIQUES BY HUNTINGTON'S CONTEMPORARIES
TOOLS FOR GENETIC DETECTION OF SUBJECTS AT RISK
From Eli Lilly and Company, Indianapolis, Ind.
Reprints: Eric Siemers, MD, Eli Lilly and Company, Lilly Corporate
Center, DC05332, Indianapolis, IN 46285 (e-mail: esiemers@lilly.com).
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ABSTRACT
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