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Arch Neurol. 2001;58:1755-1757.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

IN THE FEBRUARY 8 issues of Nature¹ and Science,² two groups reported the finishing of the first draft sequence of the human genome. Both groups, one an international public consortium, the other a publicly traded company, arrived at the draft sequence after much political strife and using somewhat different methodologies. The term draft sequence was chosen because gaps remain in the sequence, and sequence quality is not yet uniform.

Probably one of the most surprising findings in the human genome sequence was the realization that there might be fewer than 30 000 protein-coding genes. Although recent estimates of gene number had declined as rapidly as the stock market in 2000, one should not forget that estimates only a few years ago had ranged as high as 100 000 to 120 000, a number that seemed reasonable given the complexity of the human organism and the gene number in lower organisms (Table . . . [Full Text of this Article]

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