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Arch Neurol. 2001;58:1750-1751.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

THE RECENTLY completed working draft sequence of the human genome is a tool for identifying genetic causes of neurological diseases and therapeutic targets for their treatment. The emerging map contains 30 000 to 35 000 protein-coding genes and more than 2 million markers to help locate disease-causing genes.^{1, 2} These landmarks form a useful guide to navigate through vast quantities of sequence, to identify disease genes that are mutated, and to screen for therapeutic targets that might offer hope for treatments.

IDENTIFICATION OF NEW DISEASE GENES

The emerging physical map will be particularly useful to scientists searching for genes that are mutated in inherited disease. A clone-based map spanning much of the genome has been constructed, and the clones are now readily available to investigators. The clones have been placed in ordered contiguous sets, and a working draft sequence is now available for most of them. This sequence has revealed many normal variations within the human genome, including . . . [Full Text of this Article]

UNDERSTANDING MECHANISMS

THERAPEUTIC BENEFITS

WHAT LIES AHEAD