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Arch Neurol. 2000;57:1264.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

BRAIN ATROPHY has become a significant factor in the evaluation of patients with multiple sclerosis (MS). Observed over time, there seems to be a progressive loss of brain tissue that may start very early in the disease. Studies of MS at postmortem¹ have long recognized loss of brain tissue at the end of life. Recent magnetic resonance imaging (MRI) studies² have reemphasized brain and spinal cord atrophy that can be measured in life, and sequential studies have shown that the tissue loss is a progressive one.

The underlying pathological feature of atrophy is probably a mixture of demyelination and axonal loss.³ Understanding the evolution of the tissue loss will be a significant advance in MS research. Magnetic resonance methods exist that can measure indices of axonal loss (or damage). Magnetic resonance spectroscopy (MRS) can measure the N-acetyl aspartate levels, a neuronal marker, in the living brain.^4-5 Computed tomography and . . . [Full Text of this Article]

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