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Immunological Assays for Understanding Neuroimmune Interactions
Ma-Li Wong, MD;
Esther M. Sternberg, MD
Arch Neurol. 2000;57:948-952.
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INTRODUCTION
The human nervous system, particularly the central nervous system (CNS), enjoys a status of immune privilege owing to the restricted access of cells and molecules originating from the immune system. This protection from immune damage is particularly important for preservation of the CNS, since mature brain cells are terminally differentiated and are not normally replaced after death. There is now new evidence for the presence of stem cells in the brain that may be the source for neuronal cells in adulthood. This phenomenon appears to be very limited and does not compensate for the neuronal loss that occurs during pathological processes.1 Thus, the brain, unlike other organs that are composed of cell types that have the capacity to divide, is particularly vulnerable to immune-mediated damage.
In the intact mammalian CNS, lymphocytes are rarely detectable, and granulocytes and dendritic cells are absent. The CNS . . . [Full Text of this Article]
METHODS
In Situ Hybridization Histochemistry (ISHH) Western Blot Analysis Enzyme-Linked Immunoabsorbent Assay
RELEVANCE OF THE STUDY OF NEUROIMMUNE INTERACTIONS TO THE PRACTICE OF NEUROLOGY
RELEVANCE OF THE STUDY OF NEUROIMMUNE INTERACTIONS OF NEUROSCIENCE
APPLICATIONS
From the Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Md. Dr Wong is now with the UCLA Department of Psychiatry and Biobehavioral Sciences, Gonda (Goldschmeid) Neuroscience Genetics Research Center, Los Angeles, Calif.
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