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-Peptide Immunization

A Possible New Treatment for Alzheimer Disease

Dale B. Schenk, PhD; Peter Seubert, PhD; Ivan Lieberburg, MD, PhD; Jan Wallace, MD

Arch Neurol. 2000;57:934-936.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Research on the pathophysiological characteristics of Alzheimer disease (AD) over the past decade has been directed toward the ultimate goal of developing a disease-modifying treatment to control or prevent the disease. A report recently published in Nature¹ describes for the first time a treatment that may both prevent and treat the progression of Alzheimer disease. The treatment ironically involves immunization with the pathological -amyloid peptide itself to generate an immune response targeted against the amyloid plaques in the brain. These findings have raised a number of scientific and clinical questions that are discussed below.

ALZHEIMER DISEASE AND THE AMYLOID HYPOTHESIS

Pathologically, AD is characterized by atrophy of the cerebral cortex with loss of neurons and neuropil, the widespread appearance of senile amyloid plaques, and neurofibrillary tangles in the brain parenchyma of patients.^2-3 The relationship of these lesions to the cognitive dysfunction and . . . [Full Text of this Article]

-AMYLOID–RELATED THERAPEUTIC APPROACHES

-PEPTIDE AS A VACCINE REDUCES ALZHEIMER DISEASE–RELATED PATHOLOGY

QUESTIONS ARISING FROM THE -PEPTIDE VACCINATION FINDINGS

CLINICAL IMPLICATIONS

From Elan Pharmaceuticals, South San Francisco, Calif.

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