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Steven G. Kernie, MD; Luis F. Parada, PhD

Arch Neurol. 2000;57:654-657.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

The field of neurotrophin biology has made great advances in recent years to include a greater understanding of signaling pathways and broader understanding of the diverse biological roles of these molecules. This review will focus primarily on the nerve growth factor family of neurotrophins and how recent descriptions of the molecular function of both the ligands and the receptors have helped us to understand the basis for many neurologic processes. Ultimately, the goals of such studies are to give us further insight into potential diagnostic and therapeutic uses for these factors or signaling intermediates that may activate given pathways in neurotrophin signaling to achieve a particular objective based upon the underlying disease.

The prototypical neurotrophin is nerve growth factor (NGF), first described by Levi-Montalcini almost 50 years ago. The catalyst for her experiments was the observation that, in mouse sarcomas transplanted into . . . [Full Text of this Article]

NEUROTROPHIN RECEPTORS

NEUROTROPHIN PHYSIOLOGY

NEUROTROPHIN SIGNALING

RELEVANCE OF NEUROTROPHINS TO NEUROLOGIC DISEASE

THE FATE OF NEUROTROPHIN THERAPY FOR NEUROLOGIC DISEASE

From the Center for Developmental Biology (Drs Kernie and Parada) and Department of Pediatrics (Dr Kernie), University of Texas Southwestern Medical Center, Dallas.

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