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Arch Neurol. 2000;57:643-644.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

THE BOUNDARY between normal aging and very early Alzheimer disease (AD) is becoming a central focus of research. Much of the work on preventive strategies in AD is oriented toward the development of drugs, such as secretase inhibitors, or immunization techniques to prevent the onset of the disease. This work is predicated on the notion that the distinction between the cognitive changes of aging and very early AD is well delineated. It has become the responsibility of clinical investigators to characterize the transitional state between normal aging and the earliest stages of cognitive impairment.

Recent work on mild cognitive impairment (MCI) draws attention to this distinction between normal aging and very early AD.¹ A recent conference on "Current Concepts in Mild Cognitive Impairment" highlighted the heterogeneity of this concept.² Some controversy exists as to the precise manner in which to characterize these subjects, but the importance of making this distinction . . . [Full Text of this Article]

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