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The Many Faces of Charcot-Marie-Tooth Disease
Arch Neurol. 2000;57:638-640.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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We shall not cease from exploration
And the end of all our exploring
Will be to arrive where we started
And know the place for the first time.—T.S. Eliot
THE WORLD is changing because of the modern application of genetics, and the field of neurology is no exception. From trinucleotide repeats to prions, clinical and physiologic beliefs have been challenged by a continuing expansion of knowledge. The subject of the article by Nagamatsu and colleagues in this issue of the ARCHIVES,1 Charcot-Marie-Tooth disease type 2 (CMT2) has been an object of study in an increasing number of laboratories, although early genetic research involving CMT2 has already provided some interesting insights.
It was Dyck and Lambert2-3 who in 1968 first formally divided the inherited motor and sensory neuropathies into 2 types, based on physiologic and pathologic differences. Nerve biopsy findings of CMT1 showed slow nerve conduction velocities (NCVs) and onion bulbs; . . . [Full Text of this Article]
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