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Joung-Wook Lee, MD

Arch Neurol. 2000;57:597-599.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Manganese plays an important role as a cofactor in many enzymatic reactions in humans but in excess amounts can cause irreversible nervous system damage.^1-2 Although manganism is a rare condition, it can be the cause of complex nervous system symptoms, especially in the setting of environmental exposure.^3-4 Specifically, manganese is a well-known cause of dystonic parkinsonism.⁵ This article highlights several historical descriptions of the clinical manifestations, pathological changes, and attempted therapeutic intervention in manganese intoxication.

CLINICAL DESCRIPTION

In 1837, Couper⁶ described manganese intoxication in 2 patients:

Their skin is constantly covered with a layer of the oxide, and the air which they breathe is impregnated with a multitude of molecules of this oxide which are introduced into their lungs by respiration. In 1821 a young man apparently in good health, being employed at this work, presented symptoms of paraplegia which becoming worse, forced him at the end of some . . . [Full Text of this Article]

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