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Judith A. Hinchey, MD; Curtis Benesch, MD

Arch Neurol. 2000;57:1430-1436.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Stroke is the leading cause of disability in the United States and the third leading cause of death. Of long-term stroke survivors, 30% are dependent on others for help with activities of daily living and 15% require institutional care. Traditional care for patients with stroke has focused on treating complications and preventing recurrent strokes; the stroke itself was considered irreversible.

Recent trials of thrombolytic therapy, however, have engendered new hope for patients with acute ischemic stroke. Although studies of thrombolytic therapy for stroke were first published in 1958,¹ only recent trials using computed tomography (CT) and shorter therapeutic time windows (defined as time from onset of stroke symptoms to treatment) have shown beneficial results. Moreover, the term brain attack defines the approach to patients with acute ischemic stroke, replacing the nihilism of an earlier era by identifying acute ischemic stroke as a medical . . . [Full Text of this Article]

CONTROLLED TRIALS OF INTRAVENOUS (IV) THROMBOLYSIS

Tissue Plasminogen Activator

Streptokinase

CONTROLLED TRIALS OF INTRA-ARTERIAL (IA) THROMBOLYSIS

UNANSWERED QUESTIONS

From the Section of Cerebrovascular Disease, Department of Neurology, University of Rochester, Rochester, NY. Dr Hinchey is now with the Department of Neurology, Strong Memorial Hospital, Rochester, NY.

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