This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (34)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Genetic Disorders  • Alzheimer Disease  • Nutritional and Metabolic Disorders  • Lipids and Lipid Disorders  • Alert me on articles by topic

Arch Neurol. 2000;57:1410-1412.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

THE ADVENT of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, has brought a phenomenal advance to pharmacologic disease prevention. Not only has long-term therapy with these agents revolutionized the prevention of acute myocardial infarction and stroke through effective control of hyperlipidemia,^1-2 but it also seems to reduce the risk of osteoporosis³ and, now, Alzheimer disease (AD). In this issue of the ARCHIVES, Wolozin and colleagues⁴ report the results of a large observational study demonstrating the association of statin therapy with a 60% to 73% lower prevalence rate of AD. If this association turns out to be causal, it could represent an important breakthrough in the search for a medication that could prevent or arrest the most common form of dementia. However, for the statistical association to be considered causal, we must have evidence for a plausible biological mechanism for the preventive effect, and plausible alternative explanations for the statistical . . . [Full Text of this Article]

RELATED ARTICLE

Decreased Prevalence of Alzheimer Disease Associated With 3-Hydroxy-3-Methyglutaryl Coenzyme A Reductase Inhibitors
Benjamin Wolozin, Wendy Kellman, Paul Ruosseau, Gastone G. Celesia, and George Siegel
Arch Neurol. 2000;57(10):1439-1443.
ABSTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Adherence to Lipid-lowering Therapy and the Use of Preventive Health Services: An Investigation of the Healthy User Effect
Brookhart et al.
Am J Epidemiol 2007;166:348-354.
ABSTRACT | FULL TEXT  

Alzheimer-Like Changes in Rat Models of Spontaneous Diabetes
Li et al.
Diabetes 2007;56:1817-1824.
ABSTRACT | FULL TEXT  

Lipid lowering agents are associated with a slower cognitive decline in Alzheimer's disease
Masse et al.
J. Neurol. Neurosurg. Psychiatry 2005;76:1624-1629.
ABSTRACT | FULL TEXT  

Statins and cognitive function in the elderly: The Cardiovascular Health Study
Bernick et al.
Neurology 2005;65:1388-1394.
ABSTRACT | FULL TEXT  

Do Statins Reduce Risk of Incident Dementia and Alzheimer Disease?: The Cache County Study
Zandi et al.
Arch Gen Psychiatry 2005;62:217-224.
ABSTRACT | FULL TEXT  

Brain Cholesterol: Long Secret Life Behind a Barrier
Bjorkhem and Meaney
Arterioscler. Thromb. Vasc. Bio. 2004;24:806-815.
ABSTRACT | FULL TEXT  

Serum lipids and memory in a population based cohort of middle age women
Henderson et al.
J. Neurol. Neurosurg. Psychiatry 2003;74:1530-1535.
ABSTRACT | FULL TEXT  

Cholesterol and neuropathologic markers of AD: A population-based autopsy study
Adair and Launer
Neurology 2002;59:788-789.
FULL TEXT  

No Association of Paraoxonase Genotype or Atherosclerosis With Cerebral Amyloid Angiopathy
Yamada et al.
Stroke 2002;33:896-900.
ABSTRACT | FULL TEXT  

Use of Lipid-Lowering Agents, Indication Bias, and the Risk of Dementia in Community-Dwelling Elderly People
Rockwood et al.
Arch Neurol 2002;59:223-227.
ABSTRACT | FULL TEXT  

Dementia at old age: a clinical end-point of atherosclerotic disease
Blauw et al.
Eur Heart J Suppl 2001;3:N16-N19.
ABSTRACT  

Possible Relationship Between Statin Use and Decreased Incidence of Dementia: Are We Ready for a New Indication for These Drugs?
Moawad
Arch Intern Med 2001;161:1909-1910.
FULL TEXT  

Report on Statins and Dementia Disputed
Muldoon et al.
Arch Neurol 2001;58:1166-1167.
FULL TEXT  

Statins and Dementia
Golomb et al.
Arch Neurol 2001;58:1169-1170.
FULL TEXT