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John N. Whitaker, MD

Arch Neurol. 2000;57:57-58.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The study of multiple sclerosis (MS), clinically and pathologically defined in the mid-19th century, recorded numerous advancements during the last decade of the 20th century. Clinically, the disease was more accurately defined by the expected natural history, the clinical subtypes, the scoring of clinical disability, and more defined relationships to environmental factors, such as pregnancy and viral infections. Among the advancements, the notable introduction of 3 agents, interferon beta-1a, interferon beta-1b, and glatiramer acetate, improved the natural history of MS by reducing clinical relapses, delaying progression, and stabilizing the changes seen on cranial magnetic resonance images. Driven by technological expertise, the clinical value of magnetic resonance imaging is extraordinary in that it provides a noninvasive means for demonstrating the dynamic aspects of MS. However, it is essential to resolve early in the next century the discordance between clinical and imaging abnormalities and the uncertain correlative features . . . [Full Text of this Article]

From the Department of Neurology, University of Alabama at Birmingham.

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