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Roger N. Rosenberg, MD

Arch Neurol. 2000;57:50-51.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The 21st century will be the time to complete the sequencing of the human genome. The Human Genome Project has as its goal the complete nucleotide sequencing of all 3 billion nucleotides in the human haplotype by the year 2003. Preliminary restriction fragment sequences of the human genome have already been published, and single nucleotide polymorphisms linked to human characteristics and diseases will be studied intensively. It is estimated that about 100,000 to 140,000 genes are actively being transcribed in the adult neuron. Cell structures, neurotransmitters, and trophic, adhesion, and regulatory molecules that are known and function in the central nervous system will have the molecular details of their genes identified and clarified. At present, we have identified about 2000 structural and regulatory genes that are active within the central nervous system. There are approximately 5000 genetic diseases that we know of, but detailed gene sequence . . . [Full Text of this Article]

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