Botulinum Toxin in the Treatment of Neurological Disorders of the Autonomic Nervous System
Markus Naumann, MD;
Wolfgang H. Jost, MD;
Klaus V. Toyka, MD
Arch Neurol. 1999;56:914-916.
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INTRODUCTION
Botulinum neurotoxin A (BoNT/A) has become a valuable tool in the treatment of neurological disorders associated with increased muscle tone and has revolutionized the treatment of dystonia and focal spasticity. It acts at cholinergic nerve terminals by cleaving SNAP-25, a protein involved in the fusion of synaptic vesicles with the presynaptic membrane.1 Cholinergic autonomic parasympathetic and postganglionic sympathetic nerve synapses are also amenable to treatment with botulinum toxin.
Within the last few years, an increasing number of articles have been published focusing on new applications for BoNT/A. This short review gives an overview on recent indications of BoNT/A in the treatment of disorders of the autonomic nervous system and an outlook on possible future application.
TREATMENT OF AUTONOMIC DISORDERS
In view of the restricted action on the cholinergic system, potential indications for BoNT/A in disorders of the autonomic nervous system include diseases associated . . . [Full Text of this Article]
SUDOMOTOR AND SECRETOMOTOR HYPERACTIVITY
URINARY BLADDER DYSFUNCTION
GASTROINTESTINAL AND OTHER RARE INDICATIONS
CONCLUSIONS
From the Departments of Neurology, Bayerische Julius-Maximilians-Universität, Würzburg (Drs Naumann and Toyka), and Deutsche Klinik für Diagnostik, Wiesbaden (Dr Jost), Germany.
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