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Targeting in Gene Therapy for Gliomas
Juan Fueyo, MD;
Candelaria Gomez-Manzano, MD;
W. K. Alfred Yung, MD;
Athanassios P. Kyritsis, MD
Arch Neurol. 1999;56:445-448.
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INTRODUCTION
Cancer is a disease of a series of genes. Thus, theoretically, brain tumors could be treated by targeting their fundamental molecular defects. Currently, most of the approved clinical protocols for gene therapy involve cancer patients. Several of these protocols are designed to improve the treatment of brain tumors. In this brief report, we analyze the rationale, advantages, and disadvantages of a series of gene therapy approaches against brain tumors that include transfer of tumor suppressor genes and cell-cycle modulators; suicide or prodrug strategies; immunogene therapy; antiangiogenesis; and oncolytic virus therapy. In summary, in this review, we highlight the translational advances in molecular medicine that broaden our battery of therapies for patients with brain tumors.
BRAIN TUMORS
The combined incidence of all recorded primary intracranial and spinal axis tumors is between 2 and 9 in 100,000 persons per . . . [Full Text of this Article]
CELL CYCLE CONTROL AND APOPTOSIS IN GLIOMAS
The TP53 Gene The E2F-1 Pathway The MMAC1 Pathway
SUICIDE GENE THERAPIES
IMMUNOGENE THERAPY
Presentation of Tumor-Rejection Antigens by Antigen-Presenting Cells Cytokine-Expressing Tumor Cells Expression of Costimulatory Molecules on the Surface of Tumor Cells
ANTIANGIOGENESIS
ONCOLYTIC VIRUSES
Herpes Simplex Virus Replication Competent Adenovirus
COMBINATION THERAPY
From the Department of Neuro-oncology, University of Texas, M. D. Anderson Cancer Center, Houston.
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