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Current Treatment of Oligodendrogliomas
James R. Perry, MD;
David N. Louis, MD;
J. Gregory Cairncross, MD
Arch Neurol. 1999;56:434-436.
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INTRODUCTION
That a neurological review is dedicated specifically to the oligodendroglioma is testimony to a decade of progress. The unique molecular features and chemosensitivity of the oligodendroglioma were not appreciated 10 years ago; yet today, these features merit such interest to clinicians and pathologists alike that the oligodendroglioma is separated from other types of primary brain tumors in both the laboratory and in practice.
DIAGNOSIS OF OLIGODENDROGLIOMA
The diagnosis of oligodendroglioma currently rests on standard light microscopic assessment of hematoxylin-eosin–stained slides. Oligodendroglioma cells bear some resemblance to oligodendrocytes, suggesting that oligodendrogliomas arise from a cell committed to oligodendrocytic differentiation. Nonetheless, there are as yet no immunohistochemical markers to diagnose oligodendroglial neoplasms, and attempts to use various markers of oligodendrocytic differentiation have not proved reliable in tumor sections. Consequently, the pathologist renders a diagnosis of oligodendroglioma based on the subjective light microscopic impression . . . [Full Text of this Article]
OLIGODENDROGLIOMAS ARE ONE OF THE MORE CHEMOSENSITIVE HUMAN SOLID CANCERS
GENETIC PREDICTORS OF TREATMENT RESPONSE AND SURVIVAL
TREATMENT OF LOW-GRADE OLIGODENDROGLIOMAS
TREATMENT OF ANAPLASTIC OLIGODENDROGLIOMAS
From the Department of Medicine (Neurology), Toronto-Sunnybrook Regional Cancer Center, University of Toronto, Toronto, Ontario (Dr Perry); the Department of Pathology and the Neurosurgical Service, Molecular Neuro-oncology Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston (Dr Louis); and the Department of Medical Oncology, London Regional Cancer Center, London, Ontario (Dr Cairncross).
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