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Josep O. Dalmau, MD, PhD; Jerome B. Posner, MD

Arch Neurol. 1999;56:405-408.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

The fact that a small cancer hidden in the chest, abdomen, or pelvis could destroy or damage portions of the nervous system, such as cerebellar Purkinje cells or cholinergic synapses, has intrigued neurologists since paraneoplastic syndromes were first described. In 1965, when little was known about their pathogenesis, a full issue of the journal Brain and an international symposium were devoted to paraneoplastic disorders. In this decade, the discovery of several paraneoplastic antibodies that react with both the nervous system and the causal cancer has rekindled interest in these syndromes (Table 1). Several other factors make these rare syndromes of clinical and scientific interest. A recent review by Dalmau and Posner¹ contains a more comprehensive bibliography of paraneoplastic syndromes.

Table appears in full text version. Antineuronal Antibody–Associated Paraneoplastic Disorders*

These disorders challenge the diagnostic skills of the neurologist. The patient's cancer has usually not yet . . . [Full Text of this Article]

Hu ANTIGENS

Yo PROTEINS

OTHER PARANEOPLASTIC ANTIGENS

CONCLUSIONS

From the Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY.

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