This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (45)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Neurology, Other  • Alert me on articles by topic

Josep O. Dalmau, MD, PhD; Jerome B. Posner, MD

Arch Neurol. 1999;56:405-408.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

The fact that a small cancer hidden in the chest, abdomen, or pelvis could destroy or damage portions of the nervous system, such as cerebellar Purkinje cells or cholinergic synapses, has intrigued neurologists since paraneoplastic syndromes were first described. In 1965, when little was known about their pathogenesis, a full issue of the journal Brain and an international symposium were devoted to paraneoplastic disorders. In this decade, the discovery of several paraneoplastic antibodies that react with both the nervous system and the causal cancer has rekindled interest in these syndromes (Table 1). Several other factors make these rare syndromes of clinical and scientific interest. A recent review by Dalmau and Posner¹ contains a more comprehensive bibliography of paraneoplastic syndromes.

Table appears in full text version. Antineuronal Antibody–Associated Paraneoplastic Disorders*

These disorders challenge the diagnostic skills of the neurologist. The patient's cancer has usually not yet . . . [Full Text of this Article]

Hu ANTIGENS

Yo PROTEINS

OTHER PARANEOPLASTIC ANTIGENS

CONCLUSIONS

From the Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY.

RELATED ARTICLE

Archives of Neurology Reader's Choice: Continuing Medical Education
Arch Neurol. 1999;56(4):493-495.
FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Cerebellar hypermetabolism in paraneoplastic cerebellar degeneration
Choi et al.
J. Neurol. Neurosurg. Psychiatry 2006;77:525-528.
ABSTRACT | FULL TEXT  

Ataxia associated with Hashimoto's disease: progressive non-familial adult onset cerebellar degeneration with autoimmune thyroiditis
Selim and Drachman
J. Neurol. Neurosurg. Psychiatry 2001;71:81-87.
ABSTRACT | FULL TEXT  

Clinical outcome in adult onset idiopathic or paraneoplastic opsoclonus-myoclonus
Bataller et al.
Brain 2001;124:437-443.
ABSTRACT | FULL TEXT  

Classification, Clinical Manifestations, and Immunopathological Mechanisms of the Epithelial Variant of Paraneoplastic Autoimmune Multiorgan Syndrome: A Reappraisal of Paraneoplastic Pemphigus
Nguyen et al.
Arch Dermatol 2001;137:193-206.
ABSTRACT | FULL TEXT  

Serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancer
Gure et al.
Proc. Natl. Acad. Sci. USA 2000;97:4198-4203.
ABSTRACT | FULL TEXT  

Neuro-oncology 1999
Rosenberg
Arch Neurol 1999;56:397-398.
FULL TEXT