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Andrew M. Demchuk, MD, FRCPC; David C. Hess, MD; Lawrence M. Brass, MD; Frank M. Yatsu, MD

Arch Neurol. 1999;56:1518-1520.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

ATHEROSCLEROSIS is the most common cause of coronary artery disease (CAD), peripheral vascular disease, and stroke worldwide. Atherogenesis is a multifactorial process involving cholesterol internalization, vascular smooth muscle cell proliferation, inflammation, "foam cell" formation, and connective tissue production.¹ Experimental and epidemiological studies of CAD, peripheral vascular disease, and stroke have identified powerful risk factors that directly affect these multifactorial processes and include hypertension, diabetes, smoking, and aging.² The relevance of cholesterol, however, has only been definitively associated with CAD and peripheral vascular disease, and has a seemingly tentative and controversial role with strokes.^3-4 For example, in the Framingham Study⁵ no correlation was found between cholesterol and vascular disease of the brain. The Honolulu Heart Study⁶ of Japanese American men showed no significant association with cerebral infarction but an inverse relationship with intracerebral hemorrhage. . . . [Full Text of this Article]

From the Departments of Neurology, University of Texas\NHouston Medical School, Houston (Drs Demchuk and Yatsu), Medical College of Georgia and Veterans Affairs Medical Center, Augusta, Ga (Dr Hess), and Yale University School of Medicine, and Veterans Affairs Medical Center, New Haven, Conn (Dr Brass).

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