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An In Vivo Window to Study Neurodegenerative Disorders

Arch Neurol. 1999;56:1446-1447.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

DURING THE past decade, magnetic resonance spectroscopy (MRS) has proven useful in the evaluation of metabolic processes in living systems.¹ In many diseases, metabolic changes are likely to precede anatomical ones, both in the natural course of the disease and as responses to treatment. Magnetic resonance spectroscopy is sensitive to the presence of several metabolites that provide a means for early detection of diseases and treatment responses. In neurological diseases, phosphorus MRS and proton MRS are 2 major methods used to evaluate muscle and central nervous system pathology.¹ Magnetic resonance imaging can be considered a spectral localization method. It produces a spatial map of the anatomical and eventual pathological distribution of relative amounts of water and fat. Unlike magnetic resonance imaging, in MRS the data are acquired without the application of a space-encoding gradient. The pulse sequence produces a signal decay in which the spins are percussing at a frequency . . . [Full Text of this Article]