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Their Continuity With Sarcoplasmic Reticulum

Arch Neurol. 1999;56:1410-1411.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

A 45-YEAR-OLD man complained of exercise-induced muscle pain, cramps, and stiffness. Muscle biopsy specimens revealed tubular aggregates (TAs) on light microscopy (Figure 1) and electron microscopy (Figure 2, A). Tubular aggregates may be found in various neuromuscular disorders¹; they occur as irregular basophilic regions that are usually located at the edges in type II fibers (Figure 1).

Figure appears in full text version. Figure 1. Tubular aggregates on light microscopy (hematoxylin and phloxine, original magnification x500).

Figure appears in full text version. Figure 2. Tubular aggregates on electron microscopy (A, original magnification x25,000; B, original magnification x125,000; C, original magnification x125,000).

In this patient, immunohistochemical staining with calcium–adenosine triphosphatase antibodies pointed to a sarcoplasmic reticulum (SR) origin of the TAs (not shown). However, although TAs are thought to be massive proliferations of SR,² real continuity of the TAs with the SR has never been shown before. Here we see for the . . . [Full Text of this Article]

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