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Sizing Up the Brain

Arch Neurol. 1999;56:1322-1323.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

NEUROFIBROMATOSIS 1 (NF1) is one of the most common genetic disorders affecting the nervous system.¹ Individuals with NF1 manifest pigmentary abnormalities (café-au-lait macules, skin-fold freckling, and Lisch nodules) as well as benign and malignant tumors. Although NF1 commonly is regarded as an inherited predisposition to cancer syndrome, some of the most prominent features of this disorder are not attributable directly to tumor formation. In this regard, specific learning disabilities are observed in as many as 40% of children with NF1; 65% demonstrate impaired performance on at least one test of academic achievement.² These children may have difficulties with spatial memory and learning, social and/or behavioral problems, or attention-deficit/hyperactivity disorder. The etiology for these learning disabilities in NF1 is unclear. Some investigators have suggested that the presence of hyperintense lesions on T₂-weighted magnetic resonance imaging scans of the brain (unidentified bright objects [UBOs])may correlate with the presence of learning disabilities.³ . . . [Full Text of this Article]

CHICKEN OR THE EGG?


NEURONAL DEFECT?

ASTROCYTE DEFECT?

HAPLOINSUFFICIENT EFFECT?

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