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The Pathology of Shingles
Head and Campbell's 1900 Monograph
Anne Louise Oaklander, MD, PhD
Arch Neurol. 1999;56:1292-1294.
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INTRODUCTION
Shingles (herpes zoster) and postherpetic neuralgia, a chronic neuropathic pain syndrome that can persist after the shingles lesions heal,1 were studied by eminent neurologists of the 19th century. Autopsy studies were used to establish sensory neural pathways in the peripheral and central nervous systems. More recently, zoster and postherpetic neuralgia have served as models for the study of the pathogenesis and treatment of neuropathic pain. Postherpetic neuralgia has the cardinal clinical features of all neuropathic pain syndromes, including sensory abnormalities, ongoing pain, and allodynia (touch-induced pain). Unlike most other neuropathic pain syndromes, such as trigeminal neuralgia or nerve root compressions, shingles has a well-defined pathogenesis and onset, as well as visible lesions, and is therefore uniquely suitable for study.
Weller and colleagues2-3 were awarded the Nobel Prize in 1954 for isolating the varicella-zoster and polio viruses and for developing viral cultures. Two other Nobel Prizes . . . [Full Text of this Article]
EARLY HISTORY
HEAD AND CAMPBELL'S "THE PATHOLOGY OF HERPES ZOSTER AND ITS BEARING ON SENSORY LOCALIZATION"
AFTER HEAD AND CAMPBELL: 20TH-CENTURY STUDIES
From the Departments of Anesthesiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Neuropathic pain: a practical guide for the clinician.
Gilron et al.
CMAJ 2006;175:265-275.
ABSTRACT
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