Stem Cell Technology for Basic Science and Clinical Applications
Lamya S. Shihabuddin, PhD;
Jasodhara Ray, PhD;
Fred H. Gage, PhD
Arch Neurol. 1999;56:29-32.
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INTRODUCTION
In the adult mammalian central nervous system (CNS), most of the mechanisms responsible for cell proliferation and migration are shut off; thus, the capacities for self-repair and cellular replacement are greatly diminished. Observations that cell division continues in some regions of the adult brain and some resulting cells become neurons prompted attempts to identify the progenitor cells responsible for both embryonic and postnatal neural developments. The term stem cells refers to a population of cells that is capable of extended self-renewal and the ability to generate multilineage (neurons and glia) cell types (Figure 1). The growing interest in the isolation and propagation of stem cells and studying stem cell biology is driven by 2 goals. The first goal is to establish an in vitro system to ellucidate the fate pathways of individual neural progenitors. Such a system . . . [Full Text of this Article]
METHODS
RELEVANCE TO THE PRACTICE OF NEUROLOGY RELEVANCE TO THE STUDY OF NEUROSCIENCE APPLICATIONS
From Laboratory of Genetics, Salk Institute, La Jolla, Calif.
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